Jump to main content
Jump to site search


Cationic guanine: positively charged nucleobase with improved DNA affinity inhibits self-duplex formation

Author affiliations

Abstract

Oligonucleotides represent powerful DNA-recognition tools, but the formation of undesirable “self-duplexes” becomes more probable with increasing DNA affinity. Herein, we have developed a modified nucleobase with “self-avoiding” properties. Facile methylation of guanine yields a cationic N7-methylguanine, which suppresses the formation of self-duplexes whilst improving DNA affinity through electrostatic interaction.

Graphical abstract: Cationic guanine: positively charged nucleobase with improved DNA affinity inhibits self-duplex formation

Back to tab navigation

Supplementary files

Article information


Submitted
08 Jan 2020
Accepted
31 Jan 2020
First published
03 Feb 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Cationic guanine: positively charged nucleobase with improved DNA affinity inhibits self-duplex formation

M. Hibino, Y. Aiba and O. Shoji, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00169D

Social activity

Search articles by author

Spotlight

Advertisements