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Hydrophilic polyphosphoester-conjugated fluorinated chlorin as an entirely biodegradable nano-photosensitizer for reliable and efficient photodynamic therapy

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Abstract

An entirely biodegradable nano-photosensitizer platform (PPE-FP2) was fabricated by conjugating the photosensitizer TFPC to hydrophilic polyphosphoesters (PPEs) for efficiently liberating photosensitizers at the tumor site. The complete biodegradability of PPE-FP2 avoided residual nanoparticles in vivo after therapy, realizing reliable and effective photodynamic therapy.

Graphical abstract: Hydrophilic polyphosphoester-conjugated fluorinated chlorin as an entirely biodegradable nano-photosensitizer for reliable and efficient photodynamic therapy

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Article information


Submitted
07 Jan 2020
Accepted
16 Jan 2020
First published
17 Jan 2020

This article is Open Access

Chem. Commun., 2020, Advance Article
Article type
Communication

Hydrophilic polyphosphoester-conjugated fluorinated chlorin as an entirely biodegradable nano-photosensitizer for reliable and efficient photodynamic therapy

Z. Liu, M. Wu, Y. Xue, C. Chen, F. R. Wurm, M. Lan and W. Zhang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00142B

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    [Original citation] - Published by The Royal Society of Chemistry.

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