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The affinity of RSK for cylitol analogues of SL0101 is critically dependent on the B-ring C-4′-hydroxy

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Abstract

Five cyclitol analogues of SL0101 with variable substitution at the C-4′ position (i.e., OH, Cl, F, H, OMe) were synthesized. The series of analogues were evaluated for their ability to inhibit p90 ribosomal S6 kinase (RSK) activity. The study demonstrated the importance of the B-ring C-4′ hydroxy group for RSK1/2 inhibition.

Graphical abstract: The affinity of RSK for cylitol analogues of SL0101 is critically dependent on the B-ring C-4′-hydroxy

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Article information


Submitted
07 Jan 2020
Accepted
29 Jan 2020
First published
29 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

The affinity of RSK for cylitol analogues of SL0101 is critically dependent on the B-ring C-4′-hydroxy

Y. Li, P. Seber, E. B. Wright, S. Yasmin, D. A. Lannigan and G. A. O'Doherty, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00128G

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