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Formal α-trifluoromethylthiolation of carboxylic acid derivatives via N-acyl pyrazoles

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Abstract

Herein we disclosed a one-pot two-step protocol for the first direct, base-catalyzed α-trifluoromethylthiolation of carboxylic acid derivatives by using readily available N-acyl pyrazoles, N-(trifluoromethylthio)phthalimide and a nucleophile such as amines, alcohols and water. Straightforward elaboration of the products to alcohols and triflones expands further the synthetic utility of the process.

Graphical abstract: Formal α-trifluoromethylthiolation of carboxylic acid derivatives via N-acyl pyrazoles

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Article information


Submitted
06 Jan 2020
Accepted
05 Feb 2020
First published
05 Feb 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Formal α-trifluoromethylthiolation of carboxylic acid derivatives via N-acyl pyrazoles

F. Franco, S. Meninno, M. Benaglia and A. Lattanzi, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00116C

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