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Detection of atherosclerosis-related hypochlorous acid produced in foam cells with a localized endoplasmic reticulum probe

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Abstract

We have synthesized a turn-on fluorescent probe, termed NB4OH, to detect cellular hypochlorite. NB4OH is mainly localized in the endoplasmic reticulum and detects ClO in foam cells. The fluorescence change of the probe was explained by theoretical calculation as a PET process. The probe holds great promise for application in biomedical research, including atherosclerosis research.

Graphical abstract: Detection of atherosclerosis-related hypochlorous acid produced in foam cells with a localized endoplasmic reticulum probe

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Article information


Submitted
06 Jan 2020
Accepted
15 Jan 2020
First published
16 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Detection of atherosclerosis-related hypochlorous acid produced in foam cells with a localized endoplasmic reticulum probe

M. Zhang, Y. Ma, P. Li, Y. Jia and K. Han, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00090F

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