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A BODIPY-based fluorescent sensor for the detection of Pt2+ and Pt drugs

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Abstract

A BODIPY-based fluorescent sensor PS with an NO4S2 podand ligand was studied for the selective detection of Pt2+ over 21 cations as well as selected platinum drugs in aqueous medium. The platinum sensor PS shows 28-fold, 22-fold and 14-fold fluorescence turn-on enhancements to Pt2+, cisplatin and nedaplatin, and was thereby employed to detect platinum drugs in A-549 human lung cancer cells.

Graphical abstract: A BODIPY-based fluorescent sensor for the detection of Pt2+ and Pt drugs

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Article information


Submitted
02 Jan 2020
Accepted
29 Jan 2020
First published
29 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

A BODIPY-based fluorescent sensor for the detection of Pt2+ and Pt drugs

F. Tang, J. Zhu, F. K. Kong, M. Ng, Q. Bian, V. W. Yam, A. K. Tse, Y. Tse and K. C. Leung, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00027B

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