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A nitroreductase and glutathione responsive nanoplatform for integration of gene delivery and near-infrared fluorescence imaging

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Abstract

A novel platform rationally integrating indocyanine green analogues and an arginine-rich dendritic peptide with both nitroreductase (NTR) and glutathione (GSH) reduction responsive linkers was developed. This multifunctional platform can enable selective and efficient gene delivery and specific turn-on fluorescence imaging in tumors.

Graphical abstract: A nitroreductase and glutathione responsive nanoplatform for integration of gene delivery and near-infrared fluorescence imaging

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Article information


Submitted
03 Jan 2020
Accepted
11 May 2020
First published
18 May 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

A nitroreductase and glutathione responsive nanoplatform for integration of gene delivery and near-infrared fluorescence imaging

H. Liang, Q. Bi, A. Hu, X. Chen, R. Jin, X. Song, B. Ke, M. Barz and Y. Nie, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC10071G

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