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Tripeptide-induced modulation of mesenchymal stem cell biomechanics stimulates proliferation and wound healing

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Abstract

We demonstrate the ability of two tripeptides to promote proliferation and modulate the mechanical properties of human mesenchymal stem cells (hMSCs). Notably, Young's modulus of peptide-treated hMSCs was found to be ∼2 fold higher compared to the control group. These peptides promoted wound healing in hMSCs, without stimulating osteogenic and adipogenic differentiation, thus showing high potential in vascular tissue engineering applications.

Graphical abstract: Tripeptide-induced modulation of mesenchymal stem cell biomechanics stimulates proliferation and wound healing

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Submitted
29 Dec 2019
Accepted
05 Feb 2020
First published
05 Feb 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Tripeptide-induced modulation of mesenchymal stem cell biomechanics stimulates proliferation and wound healing

S. Sharma, C. Kulkarni, M. M. Kulkarni, R. Ali, K. Porwal, N. Chattopadhyay, D. Tewari and S. Verma, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC10043A

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