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Copper-catalyzed [2+3]-annulation of N–H imines with vinyl azides: access to polyaryl 2H-imidazoles

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Abstract

A practical method for the synthesis of 2H-imidazoles via a [2+3] annulation of N–H imines with vinyl azides using a copper catalyst is developed. In this conversion, environmentally friendly oxygen is used as the sole oxidant and N2 and H2O are the only by-products. The catalytic transformation, operating under mild conditions, is operationally simple and is considered as a readily available catalytic system having good substrate and functional compatibility with high atom-efficiency without the need for additional ligands or additives.

Graphical abstract: Copper-catalyzed [2+3]-annulation of N–H imines with vinyl azides: access to polyaryl 2H-imidazoles

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Supplementary files

Article information


Submitted
29 Dec 2019
Accepted
07 Apr 2020
First published
07 Apr 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Copper-catalyzed [2+3]-annulation of N–H imines with vinyl azides: access to polyaryl 2H-imidazoles

Z. Zhu, H. Lin, B. Liang, J. Huang, W. Liang, L. Chen, Y. Huang, X. Chen and Y. Li, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC10042C

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