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Folding control of a non-natural glycopeptide using saccharide-coded structural information for polypeptides

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Abstract

We synthesized “glyco-arylopeptides”, whose folding structure significantly changes depending on the kind of saccharide in their side chain. The saccharide moiety interacts with the main chain via hydrogen bonding, and the non-natural polypeptides form two well-defined architectures—(P)-31- and (M)-41-helices—depending on the length of the saccharide chains and even the configuration of a single stereo-genic center in the epimers.

Graphical abstract: Folding control of a non-natural glycopeptide using saccharide-coded structural information for polypeptides

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Article information


Submitted
30 Dec 2019
Accepted
27 Jan 2020
First published
27 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Folding control of a non-natural glycopeptide using saccharide-coded structural information for polypeptides

Y. Ishido, N. Kanbayashi, N. Fujii, T. Okamura, T. Haino and K. Onitsuka, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC10030J

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