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Fluorescence detection of metabolic activity of the fatty acid beta oxidation pathway in living cells

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Abstract

Detection of metabolic activity in living cells facilitates the understanding of the cell mechanism. Here, we report a fluorescent probe that can detect fatty acid beta oxidation (FAO) in living cells. This probe is metabolically degraded by the sequential enzyme reactions of FAO and can visualize the FAO activity with turn-on fluorescence.

Graphical abstract: Fluorescence detection of metabolic activity of the fatty acid beta oxidation pathway in living cells

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Article information


Submitted
26 Dec 2019
Accepted
05 Feb 2020
First published
05 Feb 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Fluorescence detection of metabolic activity of the fatty acid beta oxidation pathway in living cells

S. Uchinomiya, N. Matsunaga, K. Kamoda, R. Kawagoe, A. Tsuruta, S. Ohdo and A. Ojida, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09993J

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