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Iridium(i)-catalyzed hydration/esterification of 2-alkynylphenols and carboxylic acids

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Abstract

An iridium(I)-catalyzed hydration/esterification of 2-alkynylphenols and carboxylic acids is described. Various 2-alkynylphenols and carboxylic acids could be used in this process to furnish aromatic ortho-acyloxyketones via a regio- and stereo-selective addition reaction followed by intramolecular rearrangement. This protocol features mild reaction conditions and broad substrate scope. Further transformations were conducted to demonstrate the synthetic application.

Graphical abstract: Iridium(i)-catalyzed hydration/esterification of 2-alkynylphenols and carboxylic acids

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Article information


Submitted
25 Dec 2019
Accepted
05 Feb 2020
First published
06 Feb 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Iridium(I)-catalyzed hydration/esterification of 2-alkynylphenols and carboxylic acids

L. Zeng, R. Chen, C. Zhang, H. Xie and S. Cui, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09984K

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