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Dual-responsive self-assembly in lysosomes enables cell cycle arrest for locking glioma cell growth

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Abstract

Herein we first report a dual-responsive peptide substrate (Comp. 1) for preparing self-assembled nanomaterials triggered by pH and legumain. The dual-responsive self-assembly of Comp. 1 in glioma cells enables its long retention time in lysosomes, S phase arrest, and cell growth locking. We verified that the blocked degradation of HIF-1α in lysosomes played a key role in cell cycle arrest and decreased DNA replication. This work illustrates the disturbance of lysosomal function by self-assembled nanomaterials as a promising strategy for inhibiting glioma cell growth.

Graphical abstract: Dual-responsive self-assembly in lysosomes enables cell cycle arrest for locking glioma cell growth

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Article information


Submitted
25 Dec 2019
Accepted
11 May 2020
First published
13 May 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Dual-responsive self-assembly in lysosomes enables cell cycle arrest for locking glioma cell growth

J. Zhan, J. Zhong, S. Ma, W. Ma, Y. Wang, Z. Yu, Y. Cai and W. Huang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09983B

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