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The elucidation of phospholipid bilayer–small molecule interactions using a combination of phospholipid nanodiscs and solution state NMR techniques

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Abstract

Quantifying phospholipid bilayer–small molecule interactions is vital to the development of new drug candidates and/or medicinal therapies. However, obtaining these data remains problematic. Herein, we detail a phospholipid nanodisc assay which enables the elucidation of these interactions using conventional solution state NMR spectroscopy techniques.

Graphical abstract: The elucidation of phospholipid bilayer–small molecule interactions using a combination of phospholipid nanodiscs and solution state NMR techniques

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Article information


Submitted
23 Dec 2019
Accepted
05 Mar 2020
First published
05 Mar 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

The elucidation of phospholipid bilayer–small molecule interactions using a combination of phospholipid nanodiscs and solution state NMR techniques

G. Townshend, G. S. Thompson, L. J. White, J. R. Hiscock and J. L. Ortega-Roldan, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09948D

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