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Bioadhesive supramolecular hydrogel from unprotected, short d,l-peptides with Phe-Phe and Leu-Asp-Val motifs

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Abstract

The uncapped tripeptide DPhe-Phe-Leu acts as self-assembly template to yield supramolecular hydrogel biomaterials. As an example, self-assembling DPhe-Phe-Leu-Asp-Val contains the LDV bioadhesive motif for β1 integrin activation. Hydrogels made of the two peptides successfully mimic fibronectin of the extracellular matrix and lead to high cell viability, adhesion, and spreading.

Graphical abstract: Bioadhesive supramolecular hydrogel from unprotected, short d,l-peptides with Phe-Phe and Leu-Asp-Val motifs

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Article information


Submitted
23 Dec 2019
Accepted
31 Jan 2020
First published
31 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Bioadhesive supramolecular hydrogel from unprotected, short D,L-peptides with Phe-Phe and Leu-Asp-Val motifs

M. C. Cringoli, C. Romano, E. Parisi, L. J. Waddington, M. Melchionna, S. Semeraro, R. De Zorzi, M. Grönholm and S. Marchesan, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09947F

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