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Issue 17, 2020
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Asymmetric dearomatization of 2-nitrobenzofurans by organocatalyzed one-step Michael addition to access 3,3′-disubstituted oxindoles

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Abstract

An efficient enantioselective dearomatization of 2-nitrobenzofurans was realized via an organocatalyzed one-step Michael addition process. This method provides a facile strategy to access a range of structurally diverse 3,3′-disubstituted oxindoles, which feature an intriguing combination of two privileged motifs including 3-pyrrolyl-substituted-oxindoles and 2,3-dihydrobenzofurans substructures, in excellent results.

Graphical abstract: Asymmetric dearomatization of 2-nitrobenzofurans by organocatalyzed one-step Michael addition to access 3,3′-disubstituted oxindoles

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Submitted
23 Dec 2019
Accepted
27 Jan 2020
First published
28 Jan 2020

Chem. Commun., 2020,56, 2586-2589
Article type
Communication

Asymmetric dearomatization of 2-nitrobenzofurans by organocatalyzed one-step Michael addition to access 3,3′-disubstituted oxindoles

Z. Ge, L. Yang, Y. You, Z. Wang, K. Xie, M. Zhou, J. Zhao and W. Yuan, Chem. Commun., 2020, 56, 2586
DOI: 10.1039/C9CC09939E

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