Photoinduced interruption of interannular cooperativity for delivery of cationic guests in water†
The synergy among twelve carboxylates from two hexavalent baskets 16− assisted the encapsulation of one divalent diammonium guest 32+–62+ and the formation of ternary [3–6⊂12]10−. The reduction of basket's multivalency, by photoinduced α-decarboxylation of 16− to give 23−, intercepted the interannular cooperativity operating in the stabilization of capsulpex [3–6⊂12]10− to dramatically diminish the binding affinity towards diammonium guests. As a result, the cationic guests were released into bulk water with 23− assembling into nanoparticles. With numerous drugs carrying positive sites, the finding reported here could now be examined for their light-promoted spatiotemporal delivery.