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Electrochemical dehydrogenative cross-coupling of two anilines: facile synthesis of unsymmetrical biaryls

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Abstract

A new, general ortho/para-selective anodic dehydrogenative cross-coupling of two aryl amines, naphthalen-2-amine derivatives and anilines, is described. This electrochemical protocol assembles a wide range of unsymmetrical biaryls in good to excellent yields under mild, additional-metal-catalyst-free, oxidant-free conditions with excellent selectivity, broad substrate scope, and wide functional group tolerance. This electrochemical technology is highlighted with facile incorporation of important pharmacophores into the resulting biaryls, and is applicable to the homocoupling of anilines for producing symmetrical biaryls.

Graphical abstract: Electrochemical dehydrogenative cross-coupling of two anilines: facile synthesis of unsymmetrical biaryls

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Submitted
20 Dec 2019
Accepted
29 Jan 2020
First published
29 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Electrochemical dehydrogenative cross-coupling of two anilines: facile synthesis of unsymmetrical biaryls

M. Luo, Y. Li, X. Ouyang, J. Li and D. He, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09879H

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