Modulation of cyclic topology toward enhanced drug delivery, from linear and tadpole-like to dumbbell-shaped copolymers

Guiying Kang; Yuping Liu; Lingxia Li; Lu Sun; Wei Ma; Chao Meng; Liwei Ma; Guohua Zheng; Cong Chang; Hua Wei

doi:10.1039/C9CC09878J

Modulation of cyclic topology toward enhanced drug delivery, from linear and tadpole-like to dumbbell-shaped copolymers†

Guiying Kang,^a Yuping Liu,^a Lingxia Li,^b Lu Sun,^a Wei Ma,^a Chao Meng,^a Liwei Ma,^a Guohua Zheng,^c Cong Chang

*^c and Hua Wei

*^a

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* Corresponding authors

^a State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China
E-mail: weih@lzu.edu.cn

^b State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Animal Virology of the Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730000, China

^c Department of Pharmaceutics, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, China
E-mail: 1126@hbtcm.edu.cn

Abstract

In this study, an efficient strategy for the synthesis of dumbbell-shaped amphiphilic copolymers with cyclic moieties as the two bells was developed and the enhanced performance of dumbbell-shaped copolymers for controlled drug release because of the simultaneous introduction of two macrocycles was disclosed.

Chemical Communications

Modulation of cyclic topology toward enhanced drug delivery, from linear and tadpole-like to dumbbell-shaped copolymers†

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Modulation of cyclic topology toward enhanced drug delivery, from linear and tadpole-like to dumbbell-shaped copolymers

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