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A triple-helix molecular switch photoelectrochemical biosensor for ultrasensitive microRNA detection based on position-controllable CdS//CdTe signal enhancement and switching

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Abstract

Herein, a triple-helix molecular switch photoelectrochemical (PEC) biosensor is developed for ultrasensitive and selective detection of microRNA based on position-controllable CdS//CdTe signal enhancement and switching accompanying the signal amplification of a three-dimensional DNA walking machine. The developed PEC biosensor exhibits excellent analytical performance for microRNA-141 detection with a wide linear range from 5 aM to 100 fM, a low detection limit of 1.3 aM and outstanding selectivity.

Graphical abstract: A triple-helix molecular switch photoelectrochemical biosensor for ultrasensitive microRNA detection based on position-controllable CdS//CdTe signal enhancement and switching

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Article information


Submitted
20 Dec 2019
Accepted
30 Jan 2020
First published
31 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

A triple-helix molecular switch photoelectrochemical biosensor for ultrasensitive microRNA detection based on position-controllable CdS//CdTe signal enhancement and switching

W. Geng and R. Yang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09877A

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