Issue 19, 2020
From the journal:

Chemical Communications

A triple-helix molecular switch photoelectrochemical biosensor for ultrasensitive microRNA detection based on position-controllable CdS//CdTe signal enhancement and switching†

Wenchao Genga  and  Ruiying Yang ORCID logo *ab  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, P. R. China

b College of Public Health, Zhengzhou University, Zhengzhou, China
E-mail: yangruiying@zzu.edu.cn

Abstract

Herein, a triple-helix molecular switch photoelectrochemical (PEC) biosensor is developed for ultrasensitive and selective detection of microRNA based on position-controllable CdS//CdTe signal enhancement and switching accompanying the signal amplification of a three-dimensional DNA walking machine. The developed PEC biosensor exhibits excellent analytical performance for microRNA-141 detection with a wide linear range from 5 aM to 100 fM, a low detection limit of 1.3 aM and outstanding selectivity.

Graphical abstract: A triple-helix molecular switch photoelectrochemical biosensor for ultrasensitive microRNA detection based on position-controllable CdS//CdTe signal enhancement and switching

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Article information

DOI
https://doi.org/10.1039/C9CC09877A
Article type
Communication
Submitted
20 Dec 2019
Accepted
30 Jan 2020
First published
31 Jan 2020

Chem. Commun., 2020,56, 2909-2912

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A triple-helix molecular switch photoelectrochemical biosensor for ultrasensitive microRNA detection based on position-controllable CdS//CdTe signal enhancement and switching

W. Geng and R. Yang, Chem. Commun., 2020, 56, 2909 DOI: 10.1039/C9CC09877A

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