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Novel small-molecule fluorophores for in vivo NIR-IIa and NIR-IIb imaging

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Abstract

Near-infrared fluorescence imaging in the 1000–1700 nm-wavelength window (NIR-II) has exhibited great potential for deep-tissue bioimaging due to its diminished auto-fluorescence, suppressed photo-scattering, deep penetration, and high spatial and temporal resolutions. Various kinds of inorganic nanomaterials have been extensively developed for NIR-IIa (1300–1400 nm) and NIR-IIb (1500–1700 nm) bioimaging. However, the development of small-molecule NIR-IIa and NIR-IIb fluorophores is still in its infancy. Herein, we designed and synthesized a novel NIR-II organic aggregation-induced emission (AIE) fluorophore (HQL2) with a fluorescence tail extending into the NIR-IIa and NIR-IIb region based on our previous reported skeleton Q4. The encapsulated NIR-II AIE nanoparticles (HQL2 dots) exhibited water solubility and biocompatibility, and high brightness for NIR-IIa and NIR-IIb vascular imaging in vivo, a first for NIR-II AIE dots.

Graphical abstract: Novel small-molecule fluorophores for in vivo NIR-IIa and NIR-IIb imaging

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Article information


Submitted
20 Dec 2019
Accepted
05 Feb 2020
First published
05 Feb 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Novel small-molecule fluorophores for in vivo NIR-IIa and NIR-IIb imaging

Q. Li, Q. Ding, Y. Li, X. Zeng, Y. Liu, S. Lu, H. Zhou, X. Wang, J. Wu, X. Meng, Z. Deng and Y. Xiao, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09865H

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