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A β-allyl carbamate fluorescent probe for vicinal dithiol proteins

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Abstract

The first β-allyl carbamate fluorescent probe, AC-green, was reported for specifically imaging vicinal dithiol proteins (VDPs) in living systems. The probe displays low toxicity and features high sensitivity and fast response towards VDPs. A drastic loss of VDPs in a Parkinson's model was disclosed by AC-green, linking the fluctuation of VDP levels to Parkinson's disease for the first time. The structural novelty and favorable properties of AC-green will advance the development of novel VDP probes.

Graphical abstract: A β-allyl carbamate fluorescent probe for vicinal dithiol proteins

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Article information


Submitted
19 Dec 2019
Accepted
28 Jan 2020
First published
28 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

A β-allyl carbamate fluorescent probe for vicinal dithiol proteins

L. Zhao, F. Bai, F. Chen, M. Guo, L. Gan, H. Zhang and J. Fang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09841K

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