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Fluorescence resonance energy transfer (FRET)-based nanoarchitecture for monitoring deubiquitinating enzyme activity

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Abstract

A novel nanoarchitecture (MSN-Tb-UbR) was prepared by modifying rhodamine B-labelled Ubs (Ub-Rs) on the surface of mesoporous silica nanoparticles (MSNs) loaded with Tb3+-complexes. The MSN-Tb-UbR exhibits ratiometric sensing ability for DUB (UCH-L1) with good sensitivity and selectivity.

Graphical abstract: Fluorescence resonance energy transfer (FRET)-based nanoarchitecture for monitoring deubiquitinating enzyme activity

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Article information


Submitted
18 Dec 2019
Accepted
06 Feb 2020
First published
06 Feb 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Fluorescence resonance energy transfer (FRET)-based nanoarchitecture for monitoring deubiquitinating enzyme activity

Y. Liang, J. Zhang, H. Cui, Z. Shao, C. Cheng, Y. Wang and H. Wang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09808A

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