pH stimulus-disaggregated BODIPY: an activated photodynamic/photothermal sensitizer applicable to tumor ablation

Yongchao Liu; Chengyan Xu; Lili Teng; Hong-Wen Liu; Tian-Bing Ren; Shuai Xu; Xiaofeng Lou; Haowei Guo; Lin Yuan; Xiao-Bing Zhang

doi:10.1039/C9CC09790B

pH stimulus-disaggregated BODIPY: an activated photodynamic/photothermal sensitizer applicable to tumor ablation†

Yongchao Liu,^a Chengyan Xu,^a Lili Teng,^a Hong-Wen Liu,

^a Tian-Bing Ren,

^a Shuai Xu,^a Xiaofeng Lou,^a Haowei Guo,^a Lin Yuan

^a and Xiao-Bing Zhang

*^a

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* Corresponding authors

^a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University, Changsha, P. R. China
E-mail: xbzhang@hnu.edu.cn

Abstract

Herein, we report a pH stimulus-disaggregated BODIPY sensitizer (PTS) with low background-toxicity for achieving activated photodynamic/photothermal tumor therapy. Both the photodynamic and photothermal properties of PTS can be activated under acidic conditions, and PTS exhibits excellent antitumor properties, which is revealed by both in vitro and in vivo tests.

Chemical Communications

pH stimulus-disaggregated BODIPY: an activated photodynamic/photothermal sensitizer applicable to tumor ablation†

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pH stimulus-disaggregated BODIPY: an activated photodynamic/photothermal sensitizer applicable to tumor ablation

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