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Issue 27, 2020
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Peroxidation of 3,4-dihydro-1,4-benzoxazin-2-ones

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The sp3-C–H peroxidation of 3,4-dihydro-1,4-benzoxazin-2-ones was achieved under mild and simple catalyst-free reaction conditions. A range of biologically important alkylated benzoxazinone peroxides are synthesized in high yield with a good functional group tolerance. The C(sp3)-OO bond was constructed efficiently and could be further converted into C(sp3)–C(sp3), C(sp3)–C(sp2), C(sp3)–C(sp), C–P and C[double bond, length as m-dash]O bonds by late-stage functional group transformations.

Graphical abstract: Peroxidation of 3,4-dihydro-1,4-benzoxazin-2-ones

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Supplementary files

Article information

17 Dec 2019
26 Feb 2020
First published
26 Feb 2020

Chem. Commun., 2020,56, 3895-3898
Article type

Peroxidation of 3,4-dihydro-1,4-benzoxazin-2-ones

J. Wang, X. Bao, J. Wang and C. Huo, Chem. Commun., 2020, 56, 3895
DOI: 10.1039/C9CC09778C

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