Peroxidation of 3,4-dihydro-1,4-benzoxazin-2-ones†
Abstract
The sp3-C–H peroxidation of 3,4-dihydro-1,4-benzoxazin-2-ones was achieved under mild and simple catalyst-free reaction conditions. A range of biologically important alkylated benzoxazinone peroxides are synthesized in high yield with a good functional group tolerance. The C(sp3)-OO bond was constructed efficiently and could be further converted into C(sp3)–C(sp3), C(sp3)–C(sp2), C(sp3)–C(sp), C–P and CO bonds by late-stage functional group transformations.