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Rhodium-catalyzed annulative coupling of N-aryl-2-aminopyridine and propargylic amine via selective C–C and C–H bond activation

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Abstract

A Rh(III)-catalyzed/Cu(II)-mediated cascade reaction between N-aryl-2-aminopyridine and propargylic amine has been developed. Selective C(sp2)–H bond activation and C(sp)–C(sp3) cleavage occurred during the reaction, which was followed by a cyclization reaction to provide an unprecedented synthetic route to form 1,2-disubstituted indoles in yields up to 85%.

Graphical abstract: Rhodium-catalyzed annulative coupling of N-aryl-2-aminopyridine and propargylic amine via selective C–C and C–H bond activation

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Article information


Submitted
17 Dec 2019
Accepted
20 Jan 2020
First published
20 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Rhodium-catalyzed annulative coupling of N-aryl-2-aminopyridine and propargylic amine via selective C–C and C–H bond activation

S. He, X. Yan, Y. Lei, H. Xiang and X. Zhou, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09777E

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