Jump to main content
Jump to site search

Issue 15, 2020
Previous Article Next Article

Rhodium-catalyzed annulative coupling of N-aryl-2-aminopyridine and propargylic amine via selective C–C and C–H bond activation

Author affiliations

Abstract

A Rh(III)-catalyzed/Cu(II)-mediated cascade reaction between N-aryl-2-aminopyridine and propargylic amine has been developed. Selective C(sp2)–H bond activation and C(sp)–C(sp3) cleavage occurred during the reaction, which was followed by a cyclization reaction to provide an unprecedented synthetic route to form 1,2-disubstituted indoles in yields up to 85%.

Graphical abstract: Rhodium-catalyzed annulative coupling of N-aryl-2-aminopyridine and propargylic amine via selective C–C and C–H bond activation

Back to tab navigation

Supplementary files

Article information


Submitted
17 Dec 2019
Accepted
20 Jan 2020
First published
20 Jan 2020

Chem. Commun., 2020,56, 2284-2287
Article type
Communication

Rhodium-catalyzed annulative coupling of N-aryl-2-aminopyridine and propargylic amine via selective C–C and C–H bond activation

S. He, X. Yan, Y. Lei, H. Xiang and X. Zhou, Chem. Commun., 2020, 56, 2284
DOI: 10.1039/C9CC09777E

Social activity

Search articles by author

Spotlight

Advertisements