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Chemical biology of non-canonical structures of nucleic acids for therapeutic applications

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Abstract

DNA forms not only the canonical duplex structure but also non-canonical structures. Most potential sequences that induce the formation of non-canonical structures are present in disease-related genes. Interestingly, biological reactions are inhibited or dysregulated by non-canonical structure formation in disease-related genes. To control biological reactions, methods for inducing the formation of non-canonical structures have been developed using small molecules and oligonucleotides. In this feature article, we review biological reactions such as replication, transcription, and reverse transcription controlled by non-canonical DNA structures formed by disease-related genes. Furthermore, we discuss recent studies aimed at developing methods for regulating these biological reactions using drugs targeting the DNA structure.

Graphical abstract: Chemical biology of non-canonical structures of nucleic acids for therapeutic applications

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Article information


Submitted
16 Dec 2019
Accepted
28 Jan 2020
First published
28 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Feature Article

Chemical biology of non-canonical structures of nucleic acids for therapeutic applications

H. Tateishi-Karimata and N. Sugimoto, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09771F

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