Issue 16, 2020

Chemical biology of non-canonical structures of nucleic acids for therapeutic applications

Abstract

DNA forms not only the canonical duplex structure but also non-canonical structures. Most potential sequences that induce the formation of non-canonical structures are present in disease-related genes. Interestingly, biological reactions are inhibited or dysregulated by non-canonical structure formation in disease-related genes. To control biological reactions, methods for inducing the formation of non-canonical structures have been developed using small molecules and oligonucleotides. In this feature article, we review biological reactions such as replication, transcription, and reverse transcription controlled by non-canonical DNA structures formed by disease-related genes. Furthermore, we discuss recent studies aimed at developing methods for regulating these biological reactions using drugs targeting the DNA structure.

Graphical abstract: Chemical biology of non-canonical structures of nucleic acids for therapeutic applications

Article information

Article type
Feature Article
Submitted
16 Dec 2019
Accepted
28 Jan 2020
First published
28 Jan 2020

Chem. Commun., 2020,56, 2379-2390

Chemical biology of non-canonical structures of nucleic acids for therapeutic applications

H. Tateishi-Karimata and N. Sugimoto, Chem. Commun., 2020, 56, 2379 DOI: 10.1039/C9CC09771F

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