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A fluorescent naphthalimide NADH mimic for continuous and reversible sensing of cellular redox state

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Abstract

A fluorescent, naphthalimide-based, NADH mimic has been synthesised as a reversible, biocompatible, “on–off” probe for the detection of changes in intracellular redox environment (both oxidation and reduction). Interconversion was confirmed by means of electrochemistry and also 1H NMR, UV-vis and fluorescence spectroscopy. The reversibility was also successfully detected in A549 cells under simulated redox stress.

Graphical abstract: A fluorescent naphthalimide NADH mimic for continuous and reversible sensing of cellular redox state

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Article information


Submitted
16 Dec 2019
Accepted
22 Jan 2020
First published
22 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

A fluorescent naphthalimide NADH mimic for continuous and reversible sensing of cellular redox state

H. Sharma, N. K. Tan, N. Trinh, J. H. Yeo, E. J. New and F. M. Pfeffer, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09748A

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