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A superior G-quadruplex DNAzyme through functionalized modification of the hemin cofactor

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Abstract

Unlike previous studies that are generally based on the native cofactor, chemical modifications of the hemin structure through introducing new functionalities are proposed to enhance the catalytic efficiency of the hemin/G-quadruplex (hG4) DNAzyme. Functionalized hemin cofactors will highly improve the performance of the hG4 DNAzyme in future applications.

Graphical abstract: A superior G-quadruplex DNAzyme through functionalized modification of the hemin cofactor

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Article information


Submitted
17 Dec 2019
Accepted
21 Jan 2020
First published
21 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

A superior G-quadruplex DNAzyme through functionalized modification of the hemin cofactor

Y. Liu, P. Lai, J. Wang, X. Xing and L. Xu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09729E

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