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Issue 27, 2020
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l-Cysteine decorated nanoscale metal–organic frameworks delivering valproic acid/cisplatin for drug-resistant lung cancer therapy

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Abstract

We design multifunctional CDDP-VPA@ZrMOF-Cys-PEG nanoparticles (CVZP NPs) based on the properties of valproic acid (VPA) that can downregulate the expression of vascular endothelial growth factor (VEGF) to reduce the drug resistance of tumor cells. In vivo experiments confirm that chemotherapy combined with microwave thermal therapy (MWTT) can significantly improve the therapeutic effect of cisplatin-resistant lung cancer.

Graphical abstract: l-Cysteine decorated nanoscale metal–organic frameworks delivering valproic acid/cisplatin for drug-resistant lung cancer therapy

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Supplementary files

Article information


Submitted
14 Dec 2019
Accepted
28 Feb 2020
First published
28 Feb 2020

Chem. Commun., 2020,56, 3919-3922
Article type
Communication

L-Cysteine decorated nanoscale metal–organic frameworks delivering valproic acid/cisplatin for drug-resistant lung cancer therapy

W. Guo, Z. Chen, L. Tan, Q. Wu, X. Ren, C. Fu, Y. Du, J. Ren and X. Meng, Chem. Commun., 2020, 56, 3919
DOI: 10.1039/C9CC09712K

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