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A highly sensitive signal-on biosensor for microRNA 142-3p based on the quenching of Ru(bpy)32+–TPA electrochemiluminescence by carbon dots and duplex specific nuclease-assisted target recycling amplification

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Abstract

Carbon dots (CDs) have been used to quench the electrochemiluminescence (ECL) of a Ru(bpy)32+–tripropylamine (TPA) system for the first time. In addition, this phenomenon has been coupled with duplex specific nuclease-assisted target recycling amplification to develop a highly sensitive ECL biosensor for microRNA.

Graphical abstract: A highly sensitive signal-on biosensor for microRNA 142-3p based on the quenching of Ru(bpy)32+–TPA electrochemiluminescence by carbon dots and duplex specific nuclease-assisted target recycling amplification

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Article information


Submitted
14 Dec 2019
Accepted
29 Apr 2020
First published
29 Apr 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

A highly sensitive signal-on biosensor for microRNA 142-3p based on the quenching of Ru(bpy)32+–TPA electrochemiluminescence by carbon dots and duplex specific nuclease-assisted target recycling amplification

J. Yang, Q. Xia, L. Guo, F. Luo, Y. Dong, B. Qiu and Z. Lin, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09706F

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