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A molecular recognition-activatable DNA nanofirecracker enables signal-enhanced imaging in living cells

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Abstract

We propose an aptamer-tethered DNA nanofirecracker probe that realizes molecular recognition-activatable disassembly of the DNA nanostructure for imaging of target molecules in living cells. The design principle offers a new paradigm to develop nucleic acid nanocircuits for live-cell study and manipulation.

Graphical abstract: A molecular recognition-activatable DNA nanofirecracker enables signal-enhanced imaging in living cells

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Article information


Submitted
13 Dec 2019
Accepted
30 Jan 2020
First published
30 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

A molecular recognition-activatable DNA nanofirecracker enables signal-enhanced imaging in living cells

X. Xing, J. Li, L. Qiu and W. Tan, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09682E

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