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Asymmetric Si-rhodamine scaffolds: rational design of pH-durable protease-activated NIR probes in vivo

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Abstract

A group of asymmetric Si-rhodamine scaffolds was designed for protease-activated NIR probes. Dual pH-inertia for both spirocyclized fluorescent probes and fluorescent products of zwitterions form over a wide range of pH (4.0–11.0). Leucine aminopeptidase (LAP) and γ-glutamyl transpeptidase (GGT) were monitored by fluorescent imaging in vivo.

Graphical abstract: Asymmetric Si-rhodamine scaffolds: rational design of pH-durable protease-activated NIR probes in vivo

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Article information


Submitted
12 Dec 2019
Accepted
14 Jan 2020
First published
16 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Asymmetric Si-rhodamine scaffolds: rational design of pH-durable protease-activated NIR probes in vivo

M. Li, C. Wang, T. Wang, M. Fan, N. Wang, D. Ma, T. Hu and X. Cui, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09666C

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