Jump to main content
Jump to site search

Issue 17, 2020
Previous Article Next Article

Cu(i)-Catalyzed asymmetric intramolecular addition of aryl pinacolboronic esters to unactivated ketones: enantioselective synthesis of 2,3-dihydrobenzofuran-3-ol derivatives

Author affiliations

Abstract

An (S,S)-QuinoxP*-supported Cu(I) catalyst has been disclosed for highly enantioselective intramolecular addition of aryl pinacolboronic esters to unactivated ketones under mild reaction conditions. This protocol showcases a broad substrate tolerance and allows access to various chiral 2,3-dihydrobenzofuran-3-ol derivatives in generally good yields with excellent enantioselectivities.

Graphical abstract: Cu(i)-Catalyzed asymmetric intramolecular addition of aryl pinacolboronic esters to unactivated ketones: enantioselective synthesis of 2,3-dihydrobenzofuran-3-ol derivatives

Back to tab navigation

Supplementary files

Article information


Submitted
12 Dec 2019
Accepted
28 Jan 2020
First published
29 Jan 2020

Chem. Commun., 2020,56, 2654-2657
Article type
Communication

Cu(I)-Catalyzed asymmetric intramolecular addition of aryl pinacolboronic esters to unactivated ketones: enantioselective synthesis of 2,3-dihydrobenzofuran-3-ol derivatives

C. Ni, J. Gao and X. Fang, Chem. Commun., 2020, 56, 2654
DOI: 10.1039/C9CC09653A

Social activity

Search articles by author

Spotlight

Advertisements