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Observation of peroxynitrite overproduction in cells during 5-fluorouracil treatment via a ratiometric fluorescent probe

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Abstract

We describe a colorimetric and fluorescent probe 3a to detect cellular peroxynitrite with high selectivity and sensitivity. 3a was successfully applied in the bioimaging of exogenous and endogenous peroxynitrite in living cells. The up-regulation of peroxynitrite in cancer cells and normal cells during 5-fluorouracil treatment was finally monitored.

Graphical abstract: Observation of peroxynitrite overproduction in cells during 5-fluorouracil treatment via a ratiometric fluorescent probe

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Article information


Submitted
12 Dec 2019
Accepted
28 Jan 2020
First published
28 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Observation of peroxynitrite overproduction in cells during 5-fluorouracil treatment via a ratiometric fluorescent probe

J. Hou, B. Wang, Y. Zhang, B. Cui, X. Cao, M. Zhang, Y. Ye and S. Wang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09652C

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