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A novel water-soluble quinoline–indole derivative as a three-photon fluorescent probe for identifying nucleolus RNA and mitochondrial DNA

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Abstract

We present the design and synthesis of water-soluble quinoline–indole-based derivatives (IM-1, IM-2, and IM-3) with three-photon absorption activity. IM-3 can specifically target DNA and RNA accompanied by an obvious three-photon fluorescence enhancement in the second near-infrared window (1000–1700 nm). The in vitro experiments demonstrate that IM-3 can simultaneously stain mitochondria and the nucleolus both in living and fixed cells. The organelle-specific targeting behaviour is successfully visualized under stimulated emission depletion (STED) nanoscopy.

Graphical abstract: A novel water-soluble quinoline–indole derivative as a three-photon fluorescent probe for identifying nucleolus RNA and mitochondrial DNA

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Article information


Submitted
12 Dec 2019
Accepted
06 Jan 2020
First published
07 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

A novel water-soluble quinoline–indole derivative as a three-photon fluorescent probe for identifying nucleolus RNA and mitochondrial DNA

I. E. H. Elhussin, S. Zhang, J. Liu, D. Li, Q. Zhang, S. Li, X. Tian, J. Wu and Y. Tian, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09640J

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