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The regioselective annulation of alkylidenecyclopropanes by Rh(iii)-catalyzed C–H/C–C activation to access spirocyclic benzosultams

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Abstract

Functionalized benzosultams are an essential class of structural motif found in various biologically active molecules. The synthesis of spirocyclic benzosultams from N-sulfonyl ketimine and alkylidenecyclopropanes (ACPs) under the catalysis of Rh(III) has been developed. This transformation enables the formation of two C–C bonds and a double bond with high E-selectivity through C–H and C–C bond activation. This reaction proceeded smoothly with excellent regioselectivity, high efficiency, and tolerance for various functional groups.

Graphical abstract: The regioselective annulation of alkylidenecyclopropanes by Rh(iii)-catalyzed C–H/C–C activation to access spirocyclic benzosultams

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Article information


Submitted
11 Dec 2019
Accepted
03 Jan 2020
First published
04 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

The regioselective annulation of alkylidenecyclopropanes by Rh(III)-catalyzed C–H/C–C activation to access spirocyclic benzosultams

Q. Li, X. Yuan, B. Li and B. Wang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09621C

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