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A synthetic transcription factor pair mimic for precise recruitment of an epigenetic modifier to the targeted DNA locus

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Abstract

We developed an epigenetically active, cooperative DNA binding transcription factor platform assisted by cucurbit[7]uril (CB7) host–guest modules. This new type of molecule termed ePIP–HoGu not only mimics the operation of transcription factors as a pair but also recruits the epigenetic modifier to a particular DNA locus.

Graphical abstract: A synthetic transcription factor pair mimic for precise recruitment of an epigenetic modifier to the targeted DNA locus

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Article information


Submitted
11 Dec 2019
Accepted
10 Jan 2020
First published
15 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

A synthetic transcription factor pair mimic for precise recruitment of an epigenetic modifier to the targeted DNA locus

Z. Yu, M. Ai, S. K. Samanta, F. Hashiya, J. Taniguchi, S. Asamitsu, S. Ikeda, K. Hashiya, T. Bando, G. N. Pandian, L. Isaacs and H. Sugiyama, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09608F

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