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Visible photorelease of liquid biopsy markers following microfluidic affinity-enrichment

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Abstract

We detail a heterobifunctional, 7-aminocoumarin photocleavable (PC) linker with unique properties to covalently attach Abs to surfaces and subsequently release them with visible light (400–450 nm). The PC linker allowed rapid (2 min) and efficient (>90%) release of CTCs and EVs without damaging their molecular cargo.

Graphical abstract: Visible photorelease of liquid biopsy markers following microfluidic affinity-enrichment

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Article information


Submitted
14 Jan 2020
Accepted
09 Mar 2020
First published
09 Mar 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Visible photorelease of liquid biopsy markers following microfluidic affinity-enrichment

T. N. Pahattuge, J. M. Jackson, R. Digamber, H. Wijerathne, V. Brown, M. A. Witek, C. Perera, R. S. Givens, B. R. Peterson and S. A. Soper, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09598E

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