Issue 30, 2020

A phenotypic approach to probing cellular outcomes using heterobivalent constructs

Abstract

Various conjugation techniques are used to affect the intracellular delivery of bioactive small molecules. However, the ability to track changes in the phenotype when applying these tools remains poorly studied. We addressed this issue by having prepared a focused library of heterobivalent constructs based on Rho kinase inhibitor HA-100. By comparing the induction of the phenotype of interest, cell viability and cellular uptake, we demonstrate that various conjugates indeed lead to divergent cellular outcomes.

Graphical abstract: A phenotypic approach to probing cellular outcomes using heterobivalent constructs

Supplementary files

Article information

Article type
Communication
Submitted
10 Dec 2019
Accepted
10 Mar 2020
First published
10 Mar 2020

Chem. Commun., 2020,56, 4216-4219

A phenotypic approach to probing cellular outcomes using heterobivalent constructs

R. Bhadoria, K. Ping, C. Lohk, I. Järving and P. Starkov, Chem. Commun., 2020, 56, 4216 DOI: 10.1039/C9CC09595K

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