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A phenotypic approach to probing cellular outcomes using heterobivalent constructs

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Abstract

Various conjugation techniques are used to affect the intracellular delivery of bioactive small molecules. However, the ability to track changes in the phenotype when applying these tools remains poorly studied. We addressed this issue by having prepared a focused library of heterobivalent constructs based on Rho kinase inhibitor HA-100. By comparing the induction of the phenotype of interest, cell viability and cellular uptake, we demonstrate that various conjugates indeed lead to divergent cellular outcomes.

Graphical abstract: A phenotypic approach to probing cellular outcomes using heterobivalent constructs

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Article information


Submitted
10 Dec 2019
Accepted
10 Mar 2020
First published
10 Mar 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

A phenotypic approach to probing cellular outcomes using heterobivalent constructs

R. Bhadoria, K. Ping, C. Lohk, I. Järving and P. Starkov, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09595K

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