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Issue 27, 2020
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Genetically fused charged peptides induce rapid crystallization of proteins

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Abstract

We utilized electrostatic interaction to induce rapid crystallization of streptavidin. Simply mixing streptavidins possessing either a positively or negatively charged peptide at their C-terminus generated diffraction-quality crystals in a few hours. We modified the streptavidin crystals with fluorescent molecules using biotin, demonstrating the concept of protein crystals as functional biomaterials.

Graphical abstract: Genetically fused charged peptides induce rapid crystallization of proteins

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Article information


Submitted
08 Dec 2019
Accepted
29 Feb 2020
First published
02 Mar 2020

Chem. Commun., 2020,56, 3891-3894
Article type
Communication

Genetically fused charged peptides induce rapid crystallization of proteins

K. Minamihata, K. Tsukamoto, M. Adachi, R. Shimizu, M. Mishina, R. Kuroki and T. Nagamune, Chem. Commun., 2020, 56, 3891
DOI: 10.1039/C9CC09529B

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