The stereospecific Fe-catalyzed arylation of enol tosylates was reported. Various tri- or tetrasubstituted Z or E-enol tosylates of β-keto esters were arylated using common and Knochel-type Grignard reagents with complete stereofidelity. The precursors for Z/E-zimelidine, tamoxifen and other bioactive compounds were facilely prepared without precious and toxic transition metals.
Y. Wei, X. Ma, L. Wang and X. Duan, Chem. Commun., 2020, 56, 1101 DOI: 10.1039/C9CC09522E
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