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Issue 7, 2020
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Iron-catalyzed stereospecific arylation of enol tosylates using Grignard reagents

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Abstract

The stereospecific Fe-catalyzed arylation of enol tosylates was reported. Various tri- or tetrasubstituted Z or E-enol tosylates of β-keto esters were arylated using common and Knochel-type Grignard reagents with complete stereofidelity. The precursors for Z/E-zimelidine, tamoxifen and other bioactive compounds were facilely prepared without precious and toxic transition metals.

Graphical abstract: Iron-catalyzed stereospecific arylation of enol tosylates using Grignard reagents

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Supplementary files

Article information


Submitted
09 Dec 2019
Accepted
16 Dec 2019
First published
17 Dec 2019

Chem. Commun., 2020,56, 1101-1104
Article type
Communication

Iron-catalyzed stereospecific arylation of enol tosylates using Grignard reagents

Y. Wei, X. Ma, L. Wang and X. Duan, Chem. Commun., 2020, 56, 1101
DOI: 10.1039/C9CC09522E

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