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An octopus-mimic PEGylated peptide as a specific integrin αvβ3 inhibitor for preventing tumor progression

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Abstract

We have developed a multivalent PEGylated RWrNR, named octopus-R, which exhibits good water solubility, biostability, biocompatibility and cancer targeting ability, endowing it with high anticancer potential. Octopus-R represents a promising theranostic agent and holds great potential for improving the management of malignant tumors.

Graphical abstract: An octopus-mimic PEGylated peptide as a specific integrin αvβ3 inhibitor for preventing tumor progression

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Article information


Submitted
06 Dec 2019
Accepted
15 Jan 2020
First published
15 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

An octopus-mimic PEGylated peptide as a specific integrin αvβ3 inhibitor for preventing tumor progression

X. Shan, L. Zhang, Y. Xu, L. Sun, L. Guo, S. Feng, H. Ge, T. Gu and X. Ning, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09496B

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