Phototriggered labeling and crosslinking by 2-nitrobenzyl alcohol derivatives with amine selectivity

Chenxi Wang; Yuan Liu; Chunyan Bao; Yuan Xue; Yaowu Zhou; Dasheng Zhang; Qiuning Lin; Linyong Zhu

doi:10.1039/C9CC09449K

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Phototriggered labeling and crosslinking by 2-nitrobenzyl alcohol derivatives with amine selectivity†

Chenxi Wang,^a Yuan Liu,^a Chunyan Bao,

*^a Yuan Xue,^a Yaowu Zhou,^a Dasheng Zhang,^a Qiuning Lin^a and Linyong Zhu

*^a

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* Corresponding authors

^a Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, East China University of Science & Technology, Shanghai, P. R. China
E-mail: baochunyan@ecust.edu.cn, linyongzhu@ecust.edu.cn

Abstract

Here we report the use of 2-nitrobenzyl alcohol (NB) as a photoreactive group with amine selectivity and explore its applications for photoaffinity labeling and crosslinking of biomolecules. This work confirms that NB is an efficient photoreactive group and has great potential in drug discovery, chemical biology and protein engineering.

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Article information

DOI: https://doi.org/10.1039/C9CC09449K
Article type: Communication
Submitted: 05 Dec 2019
Accepted: 17 Jan 2020
First published: 17 Jan 2020

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Chem. Commun., 2020,56, 2264-2267

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Phototriggered labeling and crosslinking by 2-nitrobenzyl alcohol derivatives with amine selectivity

C. Wang, Y. Liu, C. Bao, Y. Xue, Y. Zhou, D. Zhang, Q. Lin and L. Zhu, Chem. Commun., 2020, 56, 2264 DOI: 10.1039/C9CC09449K

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Chemical Communications

Phototriggered labeling and crosslinking by 2-nitrobenzyl alcohol derivatives with amine selectivity†

Abstract

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Phototriggered labeling and crosslinking by 2-nitrobenzyl alcohol derivatives with amine selectivity

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