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Issue 15, 2020
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Phototriggered labeling and crosslinking by 2-nitrobenzyl alcohol derivatives with amine selectivity

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Abstract

Here we report the use of 2-nitrobenzyl alcohol (NB) as a photoreactive group with amine selectivity and explore its applications for photoaffinity labeling and crosslinking of biomolecules. This work confirms that NB is an efficient photoreactive group and has great potential in drug discovery, chemical biology and protein engineering.

Graphical abstract: Phototriggered labeling and crosslinking by 2-nitrobenzyl alcohol derivatives with amine selectivity

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Article information


Submitted
05 Dec 2019
Accepted
17 Jan 2020
First published
17 Jan 2020

Chem. Commun., 2020,56, 2264-2267
Article type
Communication

Phototriggered labeling and crosslinking by 2-nitrobenzyl alcohol derivatives with amine selectivity

C. Wang, Y. Liu, C. Bao, Y. Xue, Y. Zhou, D. Zhang, Q. Lin and L. Zhu, Chem. Commun., 2020, 56, 2264
DOI: 10.1039/C9CC09449K

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