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Original synthesis of radiolabeling precursors for batch and on resin one-step/late-stage radiofluorination of peptides

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Abstract

Radiolabeling of peptides with fluorine-18 is hurdled by their chemical sensitivity and complicated processes. Original triflyl-pyridine intermediates afforded ammonium precursors that were radiolabeled at low temperature. From that study, a generic tag has been designed to allow a simple one-step/late-stage radiolabelling of peptides. The strategy has been transposed to an automated “on-resin” radiolabelling.

Graphical abstract: Original synthesis of radiolabeling precursors for batch and on resin one-step/late-stage radiofluorination of peptides

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Article information


Submitted
04 Dec 2019
Accepted
27 Jan 2020
First published
27 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Original synthesis of radiolabeling precursors for batch and on resin one-step/late-stage radiofluorination of peptides

M. Richard, S. Specklin, M. Roche, F. Hinnen and B. Kuhnast, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09434B

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