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Vitamin-guanosine monophosphate conjugates for in vitro transcription priming

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Abstract

Expanding the catalytic repertoire of ribozymes to include vitamin synthesis requires efficient labelling of RNA with the substrate of interest, prior to in vitro selection. For this purpose, we rationally designed and synthesized six GMP-conjugates carrying a synthetic pre-thiamine or biotin precursor and investigated their transcription incorporation properties by T7 RNA polymerase.

Graphical abstract: Vitamin-guanosine monophosphate conjugates for in vitro transcription priming

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Article information


Submitted
04 Dec 2019
Accepted
28 Jan 2020
First published
29 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Vitamin-guanosine monophosphate conjugates for in vitro transcription priming

N. Papastavrou, O. Bande, P. Marlière, E. Groaz and P. Herdewijn, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09427J

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